Celebrex (celecoxib) is a nonsteroidal anti-inflammatory drug (NSAID). Celebrex is used to treat pain or inflammation. Celebrex is also used in the treatment of hereditary polyps in the colon. Celebrex may also be used for purposes not listed in this medication guide. Important information Do not take Celebrex if you are allergic to celecoxib, or if you have a history of allergic reaction to aspirin or other NSAIDs. Celebrex can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath. In rare cases, Celebrex may cause a severe allergic reaction. Stop taking this medicine and get emergency medical help if you have hives, severe stomach pain, difficulty breathing, swelling of your face, lips, tongue, or throat. Stop using Celebrex and call your doctor at once if you have: shortness of breath (even with mild exertion), swelling in your hands or feet; a red, blistering, peeling skin rash; bruising, severe tingling, numbness, pain, muscle weakness; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or swelling in your face, eyes, lips, tongue, or throat. Celebrex can increase your risk of bleeding, or ulcers or tear in your stomach or intestines. This effect can happen at any time while using Celebrex, but is more likely if you take it for a long time. Call your doctor at once if you have symptoms of bleeding in your digestive tract: black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds; stomach pain or cramping; or dizziness, weakness. Taking Celebrex during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not take Celebrex if you are allergic to celecoxib, or if you have: a history of allergic reaction to aspirin or other NSAIDs. To make sure Celebrex is safe for you, tell your doctor if you have ever had: heart disease, high blood pressure, congestive heart failure; a history of heart attack, stroke, or blood clot; a history of liver or kidney disease; asthma; polyps in your nose; a bleeding or blood clotting disorder; ulcerative colitis or Crohn's disease; a history of stomach bleeding; if you smoke; or if you are also taking a blood thinner such as warfarin (Coumadin). Taking Celebrex during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether celecoxib passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Do not give this medicine to a child without medical advice. Celebrex is not approved for use by anyone younger than 18 years old. How should I take Celebrex? Take Celebrex exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the lowest dose that is effective in treating your condition. Do not take this medicine in larger or smaller amounts or for longer than recommended. Celebrex can be taken with or without food. Swallow the capsule whole and do not crush, chew, or open it. If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow all of the mixture right away without chewing. Do not save it for later use. If you take celecoxib 3 times per day, do not take it more than every 8 hours. If you take celecoxib 2 times per day, do not take it more than every 12 hours. If you have trouble swallowing a celecoxib capsule, you may open the capsule and sprinkle the medicine into a half-cup (4 ounces) of applesauce. Swallow all of the mixture within 30 minutes without chewing. Do not store the mixture for later use. Discard any unused portion of celecoxib and applesauce. If you need surgery, tell the surgeon ahead of time that you are using celecoxib. You may need to stop using the medicine for a short time. Do not take celecoxib if you are pregnant. It could harm the unborn baby. Celecoxib can pass into breast milk and may cause side effects in the nursing baby. Tell your doctor if you are breast-feeding. Celebrex is not approved for use by anyone younger than 18 years old. How should I take Celebrex? Take Celebrex exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the lowest dose that is effective in treating your condition. Do not take this medicine in larger or smaller amounts or for longer than recommended. Celebrex can be taken with or without food. Swallow the capsule whole and do not crush, chew, or open it. If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow all of the mixture right away without chewing. Do not save it for later use. If you take celecoxib 3 times per day, do not take it more than every 8 hours. If you take celecoxib 2 times per day, do not take it more than every 12 hours. If you have trouble swallowing a celecoxib capsule, you may open the capsule and sprinkle the medicine into a half-cup (4 ounces) of applesauce. Swallow all of the mixture within 30 minutes without chewing. Do not store the mixture for later use. Discard any unused portion of celecoxib and applesauce. If you need surgery, tell the surgeon ahead of time that you are using celecoxib. You may need to stop using the medicine for a short time. Do not take celecoxib if you are pregnant. It could harm the unborn baby.

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