Anafranil (Clomipramine) is a tricyclic antidepressant (TCA) that is used to treat Obsessive Compulsive Disorder (OCD). It is a potent serotonin reuptake inhibitor (SSRI) and has strong anticholinergic effects. Anafranil was the first TCA to be introduced for the treatment of OCD and was approved by the FDA in August of 1989. The exact mechanism of action of Anafranil is unknown, but it is thought to work by inhibiting the reuptake of serotonin and norepinephrine in the brain. This action increases the level of these neurotransmitters in the brain, which leads to improved mood and decreased anxiety. Anafranil is a highly potent serotonin reuptake inhibitor and has a half-life of around 25 hours. Anafranil is available in generic form and brand name form. The brand name form is manufactured by Cipla and Sun Pharma. Generic Anafranil is available from various manufacturers. Anafranil is generally well-tolerated, but common side effects include dry mouth, constipation, weight gain, and drowsiness. Rare but serious side effects include seizures, QT prolongation, and mania. Anafranil is a potent medication that should be used with caution in patients with a history of seizure disorder, cardiac arrhythmias, or QT prolongation. Anafranil should be used with caution in patients with a history of mania or bipolar disorder. Anafranil is available in tablets of 10 mg, 25 mg, 50 mg, and 75 mg. The usual starting dose is 25 mg two to three times daily. The dose may be increased gradually to a maximum of 300 mg daily. Anafranil is a prescription medication that is used to treat OCD. It is a potent serotonin reuptake inhibitor and has strong anticholinergic effects. Anafranil is generally well-tolerated, but common side effects include dry mouth, constipation, weight gain, and drowsiness. Rare but serious side effects include seizures, QT prolongation, and mania.

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