ZybanZyban is a prescription medication used to treat depression and nicotine dependence. Zyban is the brand name for bupropion, a norepinephrine-dopamine reuptake inhibitor (NDRI). Zyban is available as an oral tablet and an oral extended-release tablet. The oral tablet is usually taken two or three times a day, with or without food. The extended-release tablet is usually taken once a day, with or without food. Zyban is used to treat depression and can also help people quit smoking cigarettes by reducing cravings and withdrawal symptoms. Zyban may also be used for purposes not listed in this medication guide. Zyban can cause serious side effects. Stop taking Zyban and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: fast or pounding heartbeats and sudden dizziness (like you might pass out); feeling nervous, agitated, hostile, irritable, or restless; sleep problems (insomnia); dry mouth, increased sweating; tremors or shaking; seizures (convulsions); easy bruising or bleeding, unusual weakness; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, shortness of breath; or nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious Zyban side effects may include: mild headache, mild nausea, upset stomach; mild skin rash; trouble sleeping (insomnia); or feeling tired or irritable. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Take Zyban exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Do not take this medicine with other medications that contain bupropion. Do not take Zyban within 2 weeks before or after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, or zolmitriptan. If you use Zyban to quit smoking, you may have withdrawal symptoms (headache, irritability, nausea, sleeping problems, and increased appetite). These symptoms usually last for the first few weeks of treatment, and then they get better. To make sure Zyban is safe for you, tell your doctor if you have: bipolar disorder (manic depression); a history of head injury or brain tumor; seizures (convulsions); a history of drug abuse or alcoholism; liver or kidney disease; or if you are taking insulin or diabetes medication by mouth. FDA pregnancy category C. It is not known whether Zyban will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. Do not breastfeed while you are taking Zyban. This medicine can pass into breast milk and may harm a nursing baby. Zyban may be habit-forming and should be used only by the person it was prescribed for. Zyban should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
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