Glucotrol XL (glipizide) is an oral diabetes medicine that helps control blood sugar levels. Glucotrol XL is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Glucotrol XL is not for treating type 1 diabetes. Glucotrol XL may also be used for purposes not listed in this medication guide. Important Information You should not use Glucotrol XL if you are allergic to glipizide, or if you have diabetes that is not well-controlled with diet, exercise, and weight control. To make sure Glucotrol XL is safe for you, tell your doctor if you have ever had: pancreatitis (inflammation of the pancreas); kidney disease (or if you are on dialysis); liver disease; heart disease or congestive heart failure; underactive thyroid; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); if you drink alcohol often; or if you are 65 or older. Glipizide can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Glucotrol XL. Do not give this medicine to a child without medical advice. How should I take Glucotrol XL? Take Glucotrol XL exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Glucotrol XL is usually taken once daily with breakfast or the first main meal of the day. Follow your doctor's instructions. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. If you have severe kidney disease, your body may not be able to clear this drug from your body well. This could increase the levels of Glucotrol XL in your blood and increase your risk of low blood sugar. Your doctor may start you on a lower dose or a different schedule. If you need surgery, tell the surgeon ahead of time that you are using Glucotrol XL. You should not stop using Glucotrol XL suddenly. Stopping suddenly may make your condition worse. Wear a medical alert tag or carry an ID card stating that you take Glucotrol XL. Any medical care provider who treats you should know that you take seizure medication. To be sure this medicine is helping your condition and is not causing harmful effects, your blood sugar will need to be tested often. You may also need to test your urine for sugar. Keep using this medicine even if you feel well. High blood sugar can occur even if you are following your treatment plan. Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or schedule. This medicine can cause low blood sugar (hypoglycemia). This may occur if you do not consume enough calories from food or if you do unusually heavy exercise. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good idea to carry a reliable source of glucose (such as tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency. Glucagon is a hormone that raises blood sugar. It is injected into a muscle, and works very quickly. Many people will need more than one injection of glucagon. Another person must give you this injection because you will be unable to do it yourself. Common Glucotrol XL side effects may include: headache, dizziness, lightheadedness; blurred vision; nausea, upset stomach; breast swelling or tenderness; or cold symptoms such as stuffy nose, sneezing, or sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about Glucotrol XL? You should not use Glucotrol XL if you are allergic to glipizide, or if you have diabetes that is not well-controlled with diet, exercise, and weight control. Glipizide can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Glucotrol XL. Do not give this medicine to a child without medical advice. To make sure Glucotrol XL is safe for you, tell your doctor if you have ever had: pancreatitis (inflammation of the pancreas); kidney disease (or if you are on dialysis); liver disease; heart disease or congestive heart failure; underactive thyroid; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); if you drink alcohol often; or if you are 65 or older. If you have severe kidney disease, your body may not be able to clear this drug from your body well. This could increase the levels of Glucotrol XL in your blood and increase your risk of low blood sugar. Your doctor may start you on a lower dose or a different schedule. Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or schedule. Keep using this medicine even if you feel well. High blood sugar can occur even if you are following your treatment plan. Glucotrol XL can cause low blood sugar (hypoglycemia). This may occur if you do not consume enough calories from food or if you do unusually heavy exercise. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

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