Aciphex (rabeprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Aciphex is used short-term (4 to 8 weeks) to treat erosive esophagitis (damage to the esophagus from stomach acid).

Aciphex may also be used for purposes not listed in this medication guide.

Important Information

You should not take Aciphex if you are allergic to rabeprazole.

Before taking this medicine

You should not take Aciphex if you are allergic to rabeprazole.

To make sure Aciphex is safe for you, tell your doctor if you have ever had:

  • liver disease;
  • kidney disease; or
  • low levels of magnesium in your blood.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether rabeprazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Aciphex?

Take Aciphex exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Aciphex is usually taken before breakfast. Follow your doctor's instructions.

Swallow the tablet whole and do not crush, chew, break, or sprinkle it on food.

If you cannot swallow a whole tablet, ask your doctor about other forms of rabeprazole.

Aciphex delayed-release tablets dissolve slowly in your stomach over time. The tablet shell may pass into your stools (bowel movements). This is normal and will not make the medicine less effective.

Use Aciphex for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Aciphex will not treat a viral infection such as the flu or a common cold.

Call your doctor if your symptoms do not improve, or if they get worse while taking Aciphex.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include confusion, drowsiness, and fast or pounding heartbeats.

What should I avoid while taking Aciphex?

Aciphex can cause severe side effects on the liver that may be fatal. Call your doctor at once if you have symptoms of liver damage, such as: nausea, upper stomach pain (that may spread to your back), loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

Avoid drinking alcohol.

It may increase your risk of liver damage.

Aciphex side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • loss of appetite, upper stomach pain (that may spread to your back), jaundice (yellowing of the skin or eyes);
  • kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;
  • low magnesium--dizziness, irregular heartbeats, feeling jittery, muscle cramps or weakness, spasms of the hands and feet, cough or choking feeling;
  • liver problems--nausea, upper stomach pain (that may spread to your back), loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • signs of a kidney stone--severe pain in your side or lower back, blood in your urine, painful or difficult urination;
  • high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common Aciphex side effects may include:

  • headache;
  • dizziness, drowsiness;
  • nausea, vomiting, diarrhea, gas, or abdominal pain;
  • joint pain; or
  • rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Aciphex?

Taking certain other drugs with Aciphex may increase your risk of kidney problems. Tell your doctor if you are taking:

  • an antibiotic--clarithromycin, amoxicillin, azithromycin, erythromycin, telithromycin, or troleandomycin;
  • heart rhythm medicine--amiodarone, dofetilide, dronedarone, qu

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